Ozzy & Drix

Phil LaMarr

Osmosis Jones (voice)

เจฟ เบนเนต

Drix (voice)

Alanna Ubach

Mayor Paul Spryman / Hector's Mom (voice)

Justin Cowden

Hector Cruz (voice)

Tasia Valenza

Maria Amino (voice)

Jim Cummings

Police Chief Gluteus (voice)